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Synthesis and Evaluation of Orally Active Small Molecule HIV-1 Nef Antagonists
The HIV-1 Nef accessory factor enhances viral replication and promotes immune system evasion of HIV-infected cells, making it an attractive target for drug discovery. Recently we described a novel class of diphenylpyrazolodiazene compounds that bind directly to Nef in vitro and inhibit Nef-dependent...
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| Publicado no: | Bioorg Med Chem Lett |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4756635/ https://ncbi.nlm.nih.gov/pubmed/26852364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.01.043 |
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