Effector Kinase Coupling Enables High-Throughput Screens for Direct HIV-1 Nef Antagonists with Anti-retroviral Activity

HIV-1 Nef, a critical AIDS progression factor, represents an important target protein for antiretroviral drug discovery. Because Nef lacks intrinsic enzymatic activity, we developed an assay that couples Nef to the activation of Hck, a Src-family member and Nef effector protein. Using this assay, we...

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Detalhes bibliográficos
Main Authors: Emert-Sedlak, Lori A., Narute, Purushottam, Shu, Sherry T., Poe, Jerrod A., Shi, Haibin, Yanamala, Naveena, Alvarado, John Jeff, Lazo, John S., Yeh, Joanne I., Johnston, Paul A., Smithgall, Thomas E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3559019/
https://ncbi.nlm.nih.gov/pubmed/23352142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.11.005
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