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Cell-based Fluorescence Complementation Reveals a Role for HIV-1 Nef Protein Dimerization in AP-2 Adaptor Recruitment and CD4 Co-receptor Down-regulation

The HIV-1 Nef accessory factor enhances viral infectivity, immune evasion, and AIDS progression. Nef triggers rapid down-regulation of CD4 via the endocytic adaptor protein 2 (AP-2) complex, a process linked to enhanced viral infectivity and immune escape. Here, we describe a bimolecular fluorescenc...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Shu, Sherry T., Emert-Sedlak, Lori A., Smithgall, Thomas E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314165/
https://ncbi.nlm.nih.gov/pubmed/28031466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.770016
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