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Hydrogen exchange mass spectrometry of related proteins with divergent sequences: A comparative study of HIV-1 Nef allelic variants

Hydrogen exchange mass spectrometry can be used to compare the conformation and dynamics of proteins that are similar in tertiary structure. If relative deuterium levels are measured, differences in sequence, deuterium forward- and back-exchange, peptide retention time and protease digestion pattern...

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Dettagli Bibliografici
Pubblicato in:J Am Soc Mass Spectrom
Autori principali: Wales, Thomas E., Poe, Jerrod A., Emert-Sedlak, Lori, Morgan, Christopher R., Smithgall, Thomas E., Engen, John R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865444/
https://ncbi.nlm.nih.gov/pubmed/27032648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-016-1365-5
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