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Allosteric Loss-of-function Mutations in HIV-1 Nef from a Long-Term Non-Progressor
Activation of Src family kinases by HIV-1 Nef may play an important role in the pathogenesis of HIV/AIDS. Here we investigated whether diverse Nef sequences universally activate Hck, a Src family member expressed in macrophages and other HIV-1 target cells. In general, we observed that Hck activatio...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2007
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2117379/ https://ncbi.nlm.nih.gov/pubmed/17920628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.09.009 |
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