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Hydrogen exchange mass spectrometry of related proteins with divergent sequences: A comparative study of HIV-1 Nef allelic variants

Hydrogen exchange mass spectrometry can be used to compare the conformation and dynamics of proteins that are similar in tertiary structure. If relative deuterium levels are measured, differences in sequence, deuterium forward- and back-exchange, peptide retention time and protease digestion pattern...

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Detalhes bibliográficos
Publicado no:J Am Soc Mass Spectrom
Main Authors: Wales, Thomas E., Poe, Jerrod A., Emert-Sedlak, Lori, Morgan, Christopher R., Smithgall, Thomas E., Engen, John R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865444/
https://ncbi.nlm.nih.gov/pubmed/27032648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-016-1365-5
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