A High-Fat Diet Activates Oncogenic Kras and COX2 to Induce Development of Pancreatic Ductal Adenocarcinoma in Mice

BACKGROUND & AIMS: Obesity is a risk factor for pancreatic ductal adenocarcinoma (PDAC), but it is not clear how obesity contributes to pancreatic carcinogenesis. The oncogenic form of KRAS is expressed during early stages of PDAC development, and is detected in almost all of these tumors. Howev...

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Hlavní autoři: Philip, Bincy, Roland, Christina L., Daniluk, Jaroslaw, Liu, Yan, Chatterjee, Deyali, Gomez, Sobeyda B., Ji, Baoan, Huang, Haojie, Wang, Huamin, Fleming, Jason B., Logsdon, Craig D., Cruz-Monserrate, Zobeida
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873752/
https://ncbi.nlm.nih.gov/pubmed/23958541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2013.08.018
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