An Oncogenic ALK Fusion and an RRAS Mutation in KRAS Mutation‐Negative Pancreatic Ductal Adenocarcinoma

PURPOSE. Oncogenic mutations in the KRAS gene are a well‐known driver event, occurring in >95% of pancreatic cancers. The objective of this study was to identify driver oncogene aberrations in pancreatic cancers without the KRAS mutation. METHODS. Whole‐exome and transcriptome sequencing was perf...

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Veröffentlicht in:Oncologist
Hauptverfasser: Shimada, Yoko, Kohno, Takashi, Ueno, Hideki, Ino, Yoshinori, Hayashi, Hideyuki, Nakaoku, Takashi, Sakamoto, Yasunari, Kondo, Shunsuke, Morizane, Chigusa, Shimada, Kazuaki, Okusaka, Takuji, Hiraoka, Nobuyoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: AlphaMed Press 2017
Schlagworte:
Gastrointestinal Cancer
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330701/
https://ncbi.nlm.nih.gov/pubmed/28167572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2016-0194
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