An NF-κB pathway–mediated positive feedback loop amplifies Ras activity to pathological levels in mice

Genetic mutations that give rise to active mutant forms of Ras are oncogenic and found in several types of tumor. However, such mutations are not clear biomarkers for disease, since they are frequently detected in healthy individuals. Instead, it has become clear that elevated levels of Ras activity...

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Bibliographische Detailangaben
Hauptverfasser: Daniluk, Jaroslaw, Liu, Yan, Deng, Defeng, Chu, Jun, Huang, Haojie, Gaiser, Sebastian, Cruz-Monserrate, Zobeida, Wang, Huamin, Ji, Baoan, Logsdon, Craig D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314459/
https://ncbi.nlm.nih.gov/pubmed/22406536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59743
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