An NF-κB pathway–mediated positive feedback loop amplifies Ras activity to pathological levels in mice

Genetic mutations that give rise to active mutant forms of Ras are oncogenic and found in several types of tumor. However, such mutations are not clear biomarkers for disease, since they are frequently detected in healthy individuals. Instead, it has become clear that elevated levels of Ras activity...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Daniluk, Jaroslaw, Liu, Yan, Deng, Defeng, Chu, Jun, Huang, Haojie, Gaiser, Sebastian, Cruz-Monserrate, Zobeida, Wang, Huamin, Ji, Baoan, Logsdon, Craig D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314459/
https://ncbi.nlm.nih.gov/pubmed/22406536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59743
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky