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Intracellular Trypsin Induces Pancreatic Acinar Cell Death but Not NF-κB Activation

Premature intracellular activation of the digestive enzyme trypsinogen is considered to be the initiating event in pancreatitis. However, the direct consequences of intracellular trypsin activity have not previously been examined. In the current study, a mutant trypsinogen (paired basic amino acid c...

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Hlavní autoři: Ji, Baoan, Gaiser, Sebastian, Chen, Xueqing, Ernst, Stephen A., Logsdon, Craig D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719389/
https://ncbi.nlm.nih.gov/pubmed/19383608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.005520
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