Negative Inotropic Effects of High Mobility Box Group 1 Protein in Isolated Contracting Cardiac Myocytes

HMGB1 released from necrotic cells or macrophages functions as a late inflammatory mediator, and has been shown to induce cardiovascular collapse during sepsis. Thus far, however, the effect(s) of HMGB1 in the heart are not known. We determined the effects of HMGB1 on isolated feline cardiac myocyte...

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Bibliographic Details
Main Authors: Tzeng, Huei-Ping, Fan, Jinping, Vallejo, Jesus G., Dong, Jian Wen, Chen, Xiongwen, Houser, Steven R., Mann, Douglas L.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873738/
https://ncbi.nlm.nih.gov/pubmed/18223193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00910.2007
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