Targeted Gene Silencing of Tumor Necrosis Factor Attenuates the Negative Inotropic Effects of Lipopolysaccharide in Isolated Contracting Cardiac Myocytes

Bacterial endotoxin (lipopolysaccharide) depresses cardiovascular function; however, the mediators and signaling pathways that are responsible for the negative inotropic effects of lipopolysaccharide are not fully known. We used RNA interference to determine the relative role of tumor necrosis facto...

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Huvudupphovsmän: Ramabadran, R. S., Chancey, Amanda, Vallejo, Jesus G., Barger, Philip M., Sivasubramanian, Natarajan, Mann, Douglas L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Texas Heart Institute 2008
Ämnen:
Laboratory Investigation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2322883/
https://ncbi.nlm.nih.gov/pubmed/18427645
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