The Development of Myocardial Fibrosis in Transgenic Mice with Targeted Overexpression of Tumor Necrosis Factor Requires Mast Cell-Fibroblast Interactions

BACKGROUND: Transgenic mice with cardiac restricted overexpression of tumor necrosis factor (MHCsTNF mice) develop progressive myocardial fibrosis, diastolic dysfunction and adverse cardiac remodeling. Insofar as tumor necrosis factor (TNF) does not directly stimulate fibroblast collagen synthesis,...

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Main Authors: Zhang, Weili, Chancey, Amanda L., Tzeng, Huei-Ping, Zhou, Zhenqing, Lavine, Kory, Gao, Feng, Sivasubramanian, Natarajan, Barger, Philip M., Mann, Douglas L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217207/
https://ncbi.nlm.nih.gov/pubmed/22025605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.052399
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