Necrotic Myocardial Cells Release Damage-Associated Molecular Patterns That Provoke Fibroblast Activation In Vitro and Trigger Myocardial Inflammation and Fibrosis In Vivo

BACKGROUND: Tissue injury triggers inflammatory responses that promote tissue fibrosis; however, the mechanisms that couple tissue injury, inflammation, and fibroblast activation are not known. Given that dying cells release proinflammatory “damage-associated molecular patterns” (DAMPs), we asked wh...

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Bibliographische Detailangaben
Veröffentlicht in:J Am Heart Assoc
Hauptverfasser: Zhang, Weili, Lavine, Kory J, Epelman, Slava, Evans, Sarah A, Weinheimer, Carla J, Barger, Philip M, Mann, Douglas L
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Ltd 2015
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599537/
https://ncbi.nlm.nih.gov/pubmed/26037082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.001993
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