sGCα(1) mediates the negative inotropic effects of NO in cardiac myocytes independent of changes in calcium handling

In the heart, nitric oxide (NO) modulates contractile function; however, the mechanisms responsible for this effect are incompletely understood. NO can elicit effects via a variety of mechanisms including S-nitrosylation and stimulation of cGMP synthesis by soluble guanylate cyclase (sGC). sGC is a...

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Bibliografske podrobnosti
Main Authors: Cawley, Sharon M., Kolodziej, Starsha, Ichinose, Fumito, Brouckaert, Peter, Buys, Emmanuel S., Bloch, Kenneth D.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2011
Teme:
Signaling and Stress Response
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129918/
https://ncbi.nlm.nih.gov/pubmed/21536853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01273.2010
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