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sGCα(1)β(1) attenuates cardiac dysfunction and mortality in murine inflammatory shock models

Altered cGMP signaling has been implicated in myocardial depression, morbidity, and mortality associated with sepsis. Previous studies, using inhibitors of soluble guanylate cyclase (sGC), suggested that cGMP generated by sGC contributed to the cardiac dysfunction and mortality associated with sepsi...

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Detalhes bibliográficos
Main Authors: Buys, Emmanuel S., Cauwels, Anje, Raher, Michael J., Passeri, Jonathan J., Hobai, Ion, Cawley, Sharon M., Rauwerdink, Kristen M., Thibault, Helene, Sips, Patrick Y., Thoonen, Robrecht, Scherrer-Crosbie, Marielle, Ichinose, Fumito, Brouckaert, Peter, Bloch, Kenneth D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724210/
https://ncbi.nlm.nih.gov/pubmed/19502556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00367.2009
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