sGCα(1)β(1) attenuates cardiac dysfunction and mortality in murine inflammatory shock models

Altered cGMP signaling has been implicated in myocardial depression, morbidity, and mortality associated with sepsis. Previous studies, using inhibitors of soluble guanylate cyclase (sGC), suggested that cGMP generated by sGC contributed to the cardiac dysfunction and mortality associated with sepsi...

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Autori principali: Buys, Emmanuel S., Cauwels, Anje, Raher, Michael J., Passeri, Jonathan J., Hobai, Ion, Cawley, Sharon M., Rauwerdink, Kristen M., Thibault, Helene, Sips, Patrick Y., Thoonen, Robrecht, Scherrer-Crosbie, Marielle, Ichinose, Fumito, Brouckaert, Peter, Bloch, Kenneth D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2009
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724210/
https://ncbi.nlm.nih.gov/pubmed/19502556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00367.2009
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