Performance of Common Analysis Methods for Detecting Low-Frequency Single Nucleotide Variants in Targeted Next-Generation Sequence Data

Next-generation sequencing (NGS) is becoming a common approach for clinical testing of oncology specimens for mutations in cancer genes. Unlike inherited variants, cancer mutations may occur at low frequencies because of contamination from normal cells or tumor heterogeneity and can therefore be cha...

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Bibliografski detalji
Glavni autori: Spencer, David H., Tyagi, Manoj, Vallania, Francesco, Bredemeyer, Andrew J., Pfeifer, John D., Mitra, Rob D., Duncavage, Eric J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2014
Teme:
Regular Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873500/
https://ncbi.nlm.nih.gov/pubmed/24211364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmoldx.2013.09.003
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