Performance of Common Analysis Methods for Detecting Low-Frequency Single Nucleotide Variants in Targeted Next-Generation Sequence Data

Next-generation sequencing (NGS) is becoming a common approach for clinical testing of oncology specimens for mutations in cancer genes. Unlike inherited variants, cancer mutations may occur at low frequencies because of contamination from normal cells or tumor heterogeneity and can therefore be cha...

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Main Authors: Spencer, David H., Tyagi, Manoj, Vallania, Francesco, Bredemeyer, Andrew J., Pfeifer, John D., Mitra, Rob D., Duncavage, Eric J.
格式: Artigo
語言:Inglês
出版: American Society for Investigative Pathology 2014
主題:
Regular Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873500/
https://ncbi.nlm.nih.gov/pubmed/24211364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmoldx.2013.09.003
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