Centrosomal Abnormalities Characterize Human and Rodent Cystic Cholangiocytes and Are Associated with Cdc25A Overexpression

Hepatic cystogenesis in polycystic liver diseases is associated with abnormalities of cholangiocyte cilia. Given the crucial association between cilia and centrosomes, we tested the hypothesis that centrosomal defects occur in cystic cholangiocytes of rodents (Pkd2(WS25/−) mice and PCK rats) and of...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Masyuk, Tatyana V., Lee, Seung-Ok, Radtke, Brynn N., Stroope, Angela J., Huang, Bing, Banales, Jesús M., Masyuk, Anatoliy I., Splinter, Patrick L., Gradilone, Sergio A., Gajdos, Gabriella B., LaRusso, Nicholas F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Investigative Pathology 2014
Pynciau:
Regular Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873494/
https://ncbi.nlm.nih.gov/pubmed/24211536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.09.021
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