Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD

BACKGROUND & AIMS: In polycystic liver diseases, cyst formation involves cholangiocyte hyperproliferation. In PCK rats, an animal model of autosomal recessive polycystic kidney disease (ARPKD), decreased [Ca(2+)](i) in cholangiocytes is associated with hyperproliferation. We recently showed Trpv...

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Main Authors: Gradilone, Sergio A, Masyuk, Tatyana V, Huang, Bing Q, Banales, Jesus M, Lehmann, Guillermo L, Radtke, Brynn N, Stroope, Angela, Masyuk, Anatoliy I, Splinter, Patrick L, LaRusso, Nicholas F
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902576/
https://ncbi.nlm.nih.gov/pubmed/20399209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.04.010
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