Inhibition of Cdc25A Suppresses Hepato-Renal Cystogenesis in Rodent Models of Polycystic Kidney and Liver Disease

BACKGROUND & AIMS: In polycystic kidney (PKD) and liver (PLD) diseases, the normally non-proliferative hepato-renal epithelia acquire a proliferative, cystic phenotype, which is linked to overexpression of Cdc25A and cell cycle deregulation. We investigated the effects of Cdc25A inhibition in mi...

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Main Authors: Masyuk, Tatyana V, Radtke, Brynn N, Stroope, Angela J, Banales, Jesús M, Masyuk, Anatoliy I, Gradilone, Sergio A, Gajdos, Gabriella Bedekovicsne, Chandok, Natasha, Bakeberg, Jason L, Ward, Christopher J, Ritman, Erik L, Kiyokawa, Hiroaki, LaRusso, Nicholas F
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3506023/
https://ncbi.nlm.nih.gov/pubmed/22155366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.11.036
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