Analysis of TET Expression/Activity and 5mC Oxidation during Normal and Malignant Germ Cell Development

During mammalian development the fertilized zygote and primordial germ cells lose their DNA methylation within one cell cycle leading to the concept of active DNA demethylation. Recent studies identified the TET hydroxylases as key enzymes responsible for active DNA demethylation, catalyzing the oxi...

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Autori principali: Nettersheim, Daniel, Heukamp, Lukas C., Fronhoffs, Florian, Grewe, Marc J., Haas, Natalie, Waha, Anke, Honecker, Friedemann, Waha, Andreas, Kristiansen, Glen, Schorle, Hubert
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873252/
https://ncbi.nlm.nih.gov/pubmed/24386123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082881
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