The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo

Type II testicular germ cell cancers (TGCT) are the most frequently diagnosed tumours in young men (20–40 years) and are classified as seminoma or non‐seminoma. TGCTs are commonly treated by orchiectomy and chemo‐ or radiotherapy. However, a subset of metastatic non‐seminomas (embryonal carcinomas)...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Jostes, Sina, Nettersheim, Daniel, Fellermeyer, Martin, Schneider, Simon, Hafezi, François, Honecker, Friedemann, Schumacher, Valerie, Geyer, Matthias, Kristiansen, Glen, Schorle, Hubert
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487916/
https://ncbi.nlm.nih.gov/pubmed/28026145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13059
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