Analysis of TET Expression/Activity and 5mC Oxidation during Normal and Malignant Germ Cell Development

During mammalian development the fertilized zygote and primordial germ cells lose their DNA methylation within one cell cycle leading to the concept of active DNA demethylation. Recent studies identified the TET hydroxylases as key enzymes responsible for active DNA demethylation, catalyzing the oxi...

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Main Authors: Nettersheim, Daniel, Heukamp, Lukas C., Fronhoffs, Florian, Grewe, Marc J., Haas, Natalie, Waha, Anke, Honecker, Friedemann, Waha, Andreas, Kristiansen, Glen, Schorle, Hubert
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873252/
https://ncbi.nlm.nih.gov/pubmed/24386123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082881
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