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Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention
Although Apc mutation is widely considered an initiating event in colorectal cancer, little is known about the earliest stages of tumorigenesis following sporadic Apc loss. Therefore, we have utilized a novel mouse model that facilitates the sporadic inactivation of Apc via frameshift reversion of C...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Oxford University Press
2014
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3871938/ https://ncbi.nlm.nih.gov/pubmed/23996931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgt296 |
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