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Different Phenotypic Consequences of Simultaneous Versus Stepwise Apc Loss
APC is considered a gatekeeper for colorectal cancer (CRC). Cells with heterozygous APC mutations have altered expression profiles suggesting that the first APC hit may help set the stage for subsequent transformation. Therefore, we measured transformation efficiency following what we have designate...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3235266/ https://ncbi.nlm.nih.gov/pubmed/21892206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.385 |
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