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Tractable Cre-lox system for stochastic alteration of genes in mice
We developed a cell division–activated Cre-lox system for stochastic recombination of loxP-flanked loci in mice. Cre activation by frameshift reversion is modulated by DNA mismatch-repair status and occurs in individual cells surrounded by normal tissue, mimicking spontaneous cancer-causing mutation...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2394730/ https://ncbi.nlm.nih.gov/pubmed/18264106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/NMETH.1183 |
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