Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention

Although Apc mutation is widely considered an initiating event in colorectal cancer, little is known about the earliest stages of tumorigenesis following sporadic Apc loss. Therefore, we have utilized a novel mouse model that facilitates the sporadic inactivation of Apc via frameshift reversion of C...

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Bibliographic Details
Main Authors: Fischer, Jared M., Schepers, Arnout G., Clevers, Hans, Shibata, Darryl, Liskay, R.Michael
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871938/
https://ncbi.nlm.nih.gov/pubmed/23996931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgt296
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