Different Phenotypic Consequences of Simultaneous Versus Stepwise Apc Loss

APC is considered a gatekeeper for colorectal cancer (CRC). Cells with heterozygous APC mutations have altered expression profiles suggesting that the first APC hit may help set the stage for subsequent transformation. Therefore, we measured transformation efficiency following what we have designate...

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Bibliographic Details
Main Authors: Fischer, Jared M, Miller, Ashleigh J, Shibata, Darryl, Liskay, R Michael
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235266/
https://ncbi.nlm.nih.gov/pubmed/21892206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.385
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