A Pegylated Leptin Antagonist Ameliorates CKD-Associated Cachexia in Mice

Elevated serum leptin levels correlate with inflammation and predict changes in lean body mass in patients with CKD, and activation of the melanocortin system by leptin signaling mediates the pathophysiology of CKD-associated cachexia. We tested whether treatment with a pegylated leptin receptor ant...

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Bibliografiske detaljer
Main Authors: Cheung, Wai W., Ding, Wei, Gunta, Sujana S., Gu, Yong, Tabakman, Rinat, Klapper, Leah N., Gertler, Arieh, Mak, Robert H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2014
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871780/
https://ncbi.nlm.nih.gov/pubmed/24115476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013040432
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