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Pegylated Leptin Antagonist Is a Potent Orexigenic Agent: Preparation and Mechanism of Activity

Leptin, a pleiotropic adipokine, is a central regulator of appetite and weight and a key immunomodulatory protein. Although inborn leptin deficiency causes weight gain, it is unclear whether induced leptin deficiency in adult wild-type animals would be orexigenic. Previous work with a potent competi...

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Detalhes bibliográficos
Main Authors: Elinav, Eran, Niv-Spector, Leonora, Katz, Meirav, Price, Tulin O., Ali, Mohammed, Yacobovitz, Michal, Solomon, Gili, Reicher, Shay, Lynch, Jessica L., Halpern, Zamir, Banks, William A., Gertler, Arieh
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2703547/
https://ncbi.nlm.nih.gov/pubmed/19342450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-1706
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