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The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexia

Cytokines such as IL-6, TNF-α and IL-1β trigger inflammatory cascades which may play a role in the pathogenesis of chronic kidney disease (CKD)-associated cachexia. CKD was induced by 5/6 nephrectomy in mice. We studied energy homeostasis in Il1β(−/−)/CKD, Il6(−/−)/CKD and Tnfα(−/−)/CKD mice and com...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Cheung, Wai W., Zheng, Ronghao, Hao, Sheng, Wang, Zhen, Gonzalez, Alex, Zhou, Ping, Hoffman, Hal M., Mak, Robert H.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8302616/
https://ncbi.nlm.nih.gov/pubmed/34302016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-94565-y
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