JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation

Lymphocyte recruitment is regulated by signaling modules based on the activity of Rho and Rap small guanosine triphosphatases that control integrin activation by chemokines. We show that Janus kinase (JAK) protein tyrosine kinases control chemokine-induced LFA-1– and VLA-4–mediated adhesion as well...

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Autores principales: Montresor, Alessio, Bolomini-Vittori, Matteo, Toffali, Lara, Rossi, Barbara, Constantin, Gabriela, Laudanna, Carlo
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2013
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871442/
https://ncbi.nlm.nih.gov/pubmed/24368807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201303067
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