CXCR4- and BCR-triggered integrin activation in B-cell chronic lymphocytic leukemia cells depends on JAK2-activated Bruton’s tyrosine kinase

Bruton's tyrosine kinase (BTK) regulates the B-cell receptor (BCR) signaling pathway, which, in turn, plays a critical role in B-cell chronic lymphocytic leukemia (B-CLL) pathogenesis. The BTK-specific inhibitor Ibrutinib blocks BCR signaling and is now approved as effective B-CLL therapy. Chem...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Montresor, Alessio, Toffali, Lara, Rigo, Antonella, Ferrarini, Isacco, Vinante, Fabrizio, Laudanna, Carlo
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2018
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205546/
https://ncbi.nlm.nih.gov/pubmed/30416684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26212
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