CXCR4- and BCR-triggered integrin activation in B-cell chronic lymphocytic leukemia cells depends on JAK2-activated Bruton’s tyrosine kinase

Bruton's tyrosine kinase (BTK) regulates the B-cell receptor (BCR) signaling pathway, which, in turn, plays a critical role in B-cell chronic lymphocytic leukemia (B-CLL) pathogenesis. The BTK-specific inhibitor Ibrutinib blocks BCR signaling and is now approved as effective B-CLL therapy. Chem...

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Vydáno v:Oncotarget
Hlavní autoři: Montresor, Alessio, Toffali, Lara, Rigo, Antonella, Ferrarini, Isacco, Vinante, Fabrizio, Laudanna, Carlo
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205546/
https://ncbi.nlm.nih.gov/pubmed/30416684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26212
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