Immortalization of Erythroblasts by c-MYC and BCL-XL Enables Large-Scale Erythrocyte Production from Human Pluripotent Stem Cells

The lack of knowledge about the mechanism of erythrocyte biogenesis through self-replication makes the in vitro generation of large quantities of cells difficult. We show that transduction of c-MYC and BCL-XL into multipotent hematopoietic progenitor cells derived from pluripotent stem cells and gen...

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Autori principali: Hirose, Sho-ichi, Takayama, Naoya, Nakamura, Sou, Nagasawa, Kazumichi, Ochi, Kiyosumi, Hirata, Shinji, Yamazaki, Satoshi, Yamaguchi, Tomoyuki, Otsu, Makoto, Sano, Shinya, Takahashi, Nobuyasu, Sawaguchi, Akira, Ito, Mamoru, Kato, Takashi, Nakauchi, Hiromitsu, Eto, Koji
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871399/
https://ncbi.nlm.nih.gov/pubmed/24371805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2013.10.010
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