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Novel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells
Signaling by thrombopoietin (TPO) in complex with its receptor, c-MPL, is critical for hematopoietic stem cell (HSC) homeostasis and platelet generation. Here we show that TA-316, a novel chemically synthesized c-MPL agonist (CMA), is useful for ex vivo platelet generation from human-induced pluripo...
שמור ב:
| הוצא לאור ב: | Blood Adv |
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| Main Authors: | , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society of Hematology
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5738977/ https://ncbi.nlm.nih.gov/pubmed/29296963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2016000844 |
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