Novel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells

Signaling by thrombopoietin (TPO) in complex with its receptor, c-MPL, is critical for hematopoietic stem cell (HSC) homeostasis and platelet generation. Here we show that TA-316, a novel chemically synthesized c-MPL agonist (CMA), is useful for ex vivo platelet generation from human-induced pluripo...

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Bibliografische gegevens
Gepubliceerd in:Blood Adv
Hoofdauteurs: Aihara, Ayako, Koike, Tomo, Abe, Natsuki, Nakamura, Sou, Sawaguchi, Akira, Nakamura, Takanori, Sugimoto, Naoshi, Nakauchi, Hiromitsu, Nishino, Taito, Eto, Koji
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2017
Onderwerpen:
Platelets and Thrombopoiesis
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5738977/
https://ncbi.nlm.nih.gov/pubmed/29296963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2016000844
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