Hierarchical mechanisms for transcription factor-mediated reprogramming of fibroblasts to neurons

Direct lineage reprogramming is a promising approach for human disease modeling and regenerative medicine with poorly understood mechanisms. Here we reveal a hierarchical mechanism in the direct conversion of fibroblasts into induced neuronal (iN) cells mediated by the transcription factors Ascl1, B...

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Bibliografiset tiedot
Päätekijät: Wapinski, Orly L., Vierbuchen, Thomas, Qu, Kun, Lee, Qian Yi, Chanda, Soham, Fuentes, Daniel R., Giresi, Paul G., Ng, Yi Han, Marro, Samuele, Neff, Norma F., Drechsel, Daniela, Martynoga, Ben, Castro, Diogo S., Webb, Ashley E., Brunet, Anne, Guillemot, Francois, Chang, Howard Y., Wernig, Marius
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871197/
https://ncbi.nlm.nih.gov/pubmed/24243019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.09.028
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