Hierarchical mechanisms for transcription factor-mediated reprogramming of fibroblasts to neurons

Direct lineage reprogramming is a promising approach for human disease modeling and regenerative medicine with poorly understood mechanisms. Here we reveal a hierarchical mechanism in the direct conversion of fibroblasts into induced neuronal (iN) cells mediated by the transcription factors Ascl1, B...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Wapinski, Orly L., Vierbuchen, Thomas, Qu, Kun, Lee, Qian Yi, Chanda, Soham, Fuentes, Daniel R., Giresi, Paul G., Ng, Yi Han, Marro, Samuele, Neff, Norma F., Drechsel, Daniela, Martynoga, Ben, Castro, Diogo S., Webb, Ashley E., Brunet, Anne, Guillemot, Francois, Chang, Howard Y., Wernig, Marius
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871197/
https://ncbi.nlm.nih.gov/pubmed/24243019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.09.028
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы