Hierarchical mechanisms for transcription factor-mediated reprogramming of fibroblasts to neurons

Direct lineage reprogramming is a promising approach for human disease modeling and regenerative medicine with poorly understood mechanisms. Here we reveal a hierarchical mechanism in the direct conversion of fibroblasts into induced neuronal (iN) cells mediated by the transcription factors Ascl1, B...

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Detalhes bibliográficos
Main Authors: Wapinski, Orly L., Vierbuchen, Thomas, Qu, Kun, Lee, Qian Yi, Chanda, Soham, Fuentes, Daniel R., Giresi, Paul G., Ng, Yi Han, Marro, Samuele, Neff, Norma F., Drechsel, Daniela, Martynoga, Ben, Castro, Diogo S., Webb, Ashley E., Brunet, Anne, Guillemot, Francois, Chang, Howard Y., Wernig, Marius
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871197/
https://ncbi.nlm.nih.gov/pubmed/24243019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.09.028
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