Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity

Human pluripotent stem cells can be rapidly converted into functional neurons by ectopic expression of proneural transcription factors. Here we show that directly reprogrammed neurons, despite their rapid maturation kinetics, can model teratogenic mechanisms that specifically affect early neurodevel...

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Détails bibliographiques
Publié dans:Cell Stem Cell
Auteurs principaux: Chanda, Soham, Ang, Cheen Euong, Lee, Qian Yi, Ghebrial, Michael, Haag, Daniel, Shibuya, Yohei, Wernig, Marius, Südhof, Thomas C.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609489/
https://ncbi.nlm.nih.gov/pubmed/31155484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.04.021
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