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FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice

We and others have shown that embryonic and neonatal fibroblasts can be directly converted into induced neuronal (iN) cells with mature functional properties. Reprogramming of fibroblasts from adult and aged mice, however, has not yet been explored in detail. The ability to generate fully functional...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Ahlenius, Henrik, Chanda, Soham, Webb, Ashley E., Yousif, Issa, Karmazin, Jesse, Prusiner, Stanley B., Brunet, Anne, Südhof, Thomas C., Wernig, Marius
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2016
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968717/
https://ncbi.nlm.nih.gov/pubmed/27402759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607079113
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