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FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice

We and others have shown that embryonic and neonatal fibroblasts can be directly converted into induced neuronal (iN) cells with mature functional properties. Reprogramming of fibroblasts from adult and aged mice, however, has not yet been explored in detail. The ability to generate fully functional...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ahlenius, Henrik, Chanda, Soham, Webb, Ashley E., Yousif, Issa, Karmazin, Jesse, Prusiner, Stanley B., Brunet, Anne, Südhof, Thomas C., Wernig, Marius
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968717/
https://ncbi.nlm.nih.gov/pubmed/27402759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607079113
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