Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling

The Lnk (Sh2b3) adaptor protein dampens the response of hematopoietic stem cells and progenitors (HSPCs) to a variety of cytokines by inhibiting JAK2 signaling. As a consequence, Lnk(−/−) mice develop hematopoietic hyperplasia, which progresses to a phenotype resembling the nonacute phase of myelopr...

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Detalhes bibliográficos
Main Authors: Louria-Hayon, Igal, Frelin, Catherine, Ruston, Julie, Gish, Gerald, Jin, Jing, Kofler, Michael M., Lambert, Jean-Philippe, Adissu, Hibret A., Milyavsky, Michael, Herrington, Robert, Minden, Mark D., Dick, John E., Gingras, Anne-Claude, Iscove, Norman N., Pawson, Tony
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870688/
https://ncbi.nlm.nih.gov/pubmed/24297922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319665110
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