Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation

The lymphocyte adaptor protein LNK (also known as SH2B3) is primarily expressed in hematopoietic and endothelial cells, where it functions as a negative regulator of cytokine signaling and cell proliferation. Single-nucleotide polymorphisms in the gene encoding LNK are associated with autoimmune and...

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Udgivet i:J Clin Invest
Main Authors: Saleh, Mohamed A., McMaster, William G., Wu, Jing, Norlander, Allison E., Funt, Samuel A., Thabet, Salim R., Kirabo, Annet, Xiao, Liang, Chen, Wei, Itani, Hana A., Michell, Danielle, Huan, Tianxiao, Zhang, Yahua, Takaki, Satoshi, Titze, Jens, Levy, Daniel, Harrison, David G., Madhur, Meena S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362266/
https://ncbi.nlm.nih.gov/pubmed/25664851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76327
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