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CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli

RATIONALE: Accumulating evidence supports a role of adaptive immunity and particularly T cells in the pathogenesis of hypertension. Formation of memory T cells, which requires the co-stimulatory molecule CD70 on antigen presenting cells, is a cardinal feature of adaptive immunity. OBJECTIVE: To test...

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Detalhes bibliográficos
Publicado no:Circ Res
Main Authors: Itani, Hana A., Xiao, Liang, Saleh, Mohamed A., Wu, Jing, Pilkinton, Mark A., Dale, Bethany L., Barbaro, Natalia R., Foss, Jason D., Kirabo, Annet, Montaniel, Kim R., Norlander, Allison E., Chen, Wei, Sato, Ryosuke, Navar, L. Gabriel, Mallal, Simon A., Madhur, Meena S., Bernstein, Kenneth E., Harrison, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833561/
https://ncbi.nlm.nih.gov/pubmed/26988069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.308111
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