CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli

RATIONALE: Accumulating evidence supports a role of adaptive immunity and particularly T cells in the pathogenesis of hypertension. Formation of memory T cells, which requires the co-stimulatory molecule CD70 on antigen presenting cells, is a cardinal feature of adaptive immunity. OBJECTIVE: To test...

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Udgivet i:Circ Res
Main Authors: Itani, Hana A., Xiao, Liang, Saleh, Mohamed A., Wu, Jing, Pilkinton, Mark A., Dale, Bethany L., Barbaro, Natalia R., Foss, Jason D., Kirabo, Annet, Montaniel, Kim R., Norlander, Allison E., Chen, Wei, Sato, Ryosuke, Navar, L. Gabriel, Mallal, Simon A., Madhur, Meena S., Bernstein, Kenneth E., Harrison, David G.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833561/
https://ncbi.nlm.nih.gov/pubmed/26988069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.308111
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