Induction of HIV-1 broad neutralizing antibodies in 2F5 knockin mice: selection against MPER-associated autoreactivity limits T-dependent responses

A goal of HIV-1 vaccine development is to elicit broadly neutralizing antibodies (BnAbs). Using a knock-in (KI) model of 2F5, a human HIV-1 gp41 MPER-specific BnAb, we previously demonstrated that a key obstacle to BnAb induction is clonal deletion of BnAb-expressing B-cells. Here, in this model, we...

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Main Authors: Verkoczy, Laurent, Chen, Yao, Zhang, Jinsong, Bouton-Verville, Hilary, Newman, Amanda, Lockwood, Bradley, Scearce, Richard M., Montefiori, David C., Dennison, S. Moses, Xia, Shi-Mao, Hwang, Kwan-Ki, Liao, Hua-Xin, Alam, S.Munir, Haynes, Barton F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870053/
https://ncbi.nlm.nih.gov/pubmed/23918977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300971
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