Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10()

Developing an HIV-1 vaccine has been hampered by the inability of immunogens to induce broadly neutralizing antibodies (bnAbs) that protect against infection. Previously, we used knockin (KI) mice expressing a prototypical gp41-specific bnAb, 2F5, to demonstrate that immunological tolerance triggere...

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Main Authors: Chen, Yao, Zhang, Jinsong, Hwang, Kwan-Ki, Bouton-Verville, Hilary, Xia, Shi-Mao, Newman, Amanda, Ouyang, Ying-Bin, Haynes, Barton F., Verkoczy, Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725147/
https://ncbi.nlm.nih.gov/pubmed/23825311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300770
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