Initiation of immune tolerance–controlled HIV gp41 neutralizing B cell lineages

Development of an HIV vaccine is a global priority. A major roadblock to a vaccine is an inability to induce protective broadly neutralizing antibodies (bnAbs). HIV gp41 bnAbs have characteristics that predispose them to be controlled by tolerance. We used gp41 2F5 bnAb germline knock-in mice and ma...

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Udgivet i:Sci Transl Med
Main Authors: Zhang, Ruijun, Verkoczy, Laurent, Wiehe, Kevin, Alam, S. Munir, Nicely, Nathan I., Santra, Sampa, Bradley, Todd, Pemble, Charles W., Zhang, Jinsong, Gao, Feng, Montefiori, David C., Bouton-Verville, Hilary, Kelsoe, Garnett, Larimore, Kevin, Greenberg, Phillip D., Parks, Robert, Foulger, Andrew, Peel, Jessica N., Luo, Kan, Lu, Xiaozhi, Trama, Ashley M., Vandergrift, Nathan, Tomaras, Georgia D., Kepler, Thomas B., Moody, M. Anthony, Liao, Hua-Xin, Haynes, Barton F.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006673/
https://ncbi.nlm.nih.gov/pubmed/27122615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf0618
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