HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism

The HIV-1 envelope protein (Env) has evolved to subvert the host immune system, hindering viral control by the host. The tryptophan metabolic enzyme kynureninase (KYNU) is mimicked by a portion of the HIV Env gp41 membrane proximal region (MPER) and is cross-reactive with the HIV broadly neutralizin...

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Publicado no:J Immunol
Main Authors: Bradley, Todd, Yang, Guang, Ilkayeva, Olga, Holl, T. Matt, Zhang, Ruijun, Zhang, Jinsong, Santra, Sampa, Fox, Christopher B., Reed, Steve G., Parks, Robert, Bowman, Cindy M., Bouton-Verville, Hilary, Sutherland, Laura L., Scearce, Richard M., Vandergrift, Nathan, Kepler, Thomas B., Moody, M. Anthony, Liao, Hua-Xin, Alam, S. Munir, McLendon, Roger, Everitt, Jeffrey I., Newgard, Christopher B., Verkoczy, Laurent, Kelsoe, Garnett, Haynes, Barton F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136304/
https://ncbi.nlm.nih.gov/pubmed/27849170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601484
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