mTORC2 regulates mechanically induced cytoskeletal reorganization and lineage selection in marrow derived mesenchymal stem cells

The cell cytoskeleton interprets and responds to physical cues from the microenvironment. Applying mechanical force to mesenchymal stem cells induces formation of a stiffer cytoskeleton, which biases against adipogenic differentiation and toward osteoblastogenesis. mTORC2, the mTOR complex defined b...

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Bibliographic Details
Main Authors: Sen, Buer, Xie, Zhihui, Case, Natasha, Thompson, William R., Uzer, Gunes, Styner, Maya, Rubin, Janet
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870029/
https://ncbi.nlm.nih.gov/pubmed/23821483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2031
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